PAF is a potent pyrogen and cryogen in rodents, but it does not mediate thermoregulatory responses to bacterial endotoxin
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چکیده
Concordance between lipopolysaccharide and platelet activating factor - mediated events have suggested that the latter likely mediates all effects induced by the former. In this issue of Temperature, Steiner and Romanovsky challenge this notion, showing that while platelet activating factor is a potent pyrogenic mediator, the thermoregulatory responses to lipopolysaccharide are instead induced by prostaglandins.
منابع مشابه
Platelet-activating factor is a potent pyrogen and cryogen, but it does not mediate lipopolysaccharide fever or hypothermia.
We examined whether platelet-activating factor (PAF) and its receptor mediate lipopolysaccharide (LPS)-induced fever and hypothermia in rats. Two highly potent, structurally distinct antagonists of the PAF receptor, CV6209 and WEB2086, were used. At a neutral ambient temperature (Ta) of 30ºC, administration of LPS at a low (10 μg/kg, i.v.) or high (1,000 μg/kg, i.v.) dose resulted in fever. The...
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